This is one such case report documenting arterial thrombosis in a 37-year-old male with a subsequently
identified heterozygous Factor V Leiden mutation.
Factor V Leiden mutation is a contributing risk factor in cases of small bowel infarction.”
“BackgroundBK virus (BKV)-associated hemorrhagic cystitis (BKV-HC) is a severe complication after hematopoietic stem cell transplantation (HSCT). Cidofovir (CDV) has emerged as an effective agent for the treatment of BKV OICR-9429 purchase nephropathy, but its use for BKV-HC in pediatric HSCT recipients has not yet been established as a standard therapy.
Patient and methodsWe retrospectively investigated the efficacy and safety of CDV therapy for patients with BKV-HC at a single institution and analyzed the clinical management outcomes.
ResultsFrom find more April 2009 to July 2011, 12 patients developed BKV-HC at a median of 37days after transplant (range 15-59days). The cumulative incidence was 9% and the median peak of the urine BKV load was 2.5×10(10) copies/mL (range 1.4×10(9)-1.2×10(11) copies/mL). Eleven patients received intravenous CDV (5mg/kg/dose, with probenecid), whereas 1 patient received CDV (5mg/kg/dose, without probenecid) intravesically. The median duration of therapy was 25days (range 9-73days), and a median of 2 doses was given (range 1-4). A reduction of 1 log in the BKV load was found
in 11 patients, while 1 patient did not have any significant change in BKV load. Clinical improvement was observed in all cases, and no HC-related death was observed. CDV-related Z-DEVD-FMK in vitro toxicity occurred in 1 patient (8%) and spontaneously resolved.
ConclusionsCDV appears to be an effective and safe treatment for BKV-HC in pediatric HSCT recipients, but prospective trials are warranted to support its use.”
“A series of new thiazolyl chalcones, 1-[2-amino-4-methyl-1,3-thiazol-5-yl]-3-aryl-prop-2-en-1-one were prepared by piperidine mediated Claisen-Schmidt condensation of thiazolyl ketone with aromatic aldehyde. These chalcones on cyclisation
gave 2-amino-6-(2-amino-4-methyl-1,3-thiazol-5-yl)-4-aryl-4H-pyridine-3-carbonitrile and 2-amino-6-(2-amino-4-methyl-1,3-thiazol-5-yl)-4-aryl-4H-pyran-3-carbonitrile. The result showed that the compounds exhibited marked potency as antimicrobial agents.”
“Spontaneous rapid resolution of acute subdural hematoma (ASDH) is a rare phenomenon for this severe insult after head trauma.
We present a 22-year-old patient who developed ASDH with a moderate midline shift and compression of lateral ventricle after a truncal collision but without a direct beat on the head. Conservative management was performed under close monitoring because of unexpected improvement of clinical signs and symptoms. Unexpectedly, the ASDH resolved spontaneously within 13 h after the trauma, and he was discharged 1 week later without any neurological deficit. In addition, similar cases reported in literature were reviewed.