pylori infection, providing gastroscopic features as clinical evidence to those patients who take H.pylori tests in their body of stomach. Methods: Gastroscopy patients were enrolled in the Peking University People’s Hospital between Dec. 2009 and Apr. 2013. Results of pathological diagnosis, H. pylori antibody, Rapid Urease
Test (RUT), gastroscopy diagnosis and appearance of cracks in the body of stomach were collected in each patient. Results: 248 of 590 patients (42.03%) are H. pylori positive, of which 77.42% (192/248) is H. pylori positive in both of gastric antrum and body, SAHA HDAC manufacturer 20.16% (50/248) is H. pylori positive only in antrum, and 2.42% (6/248) is H. pylori positive only in the body of stomach. The H. pylori positivity is 66.8% (173/259) and 22.7% (75/331) respectively in the group with or without the presence of cracks
in body (χ2 = 116.172, P = 0.000). It is showed that the presence of cracks in gastric body is related with severity of gastric inflammation (P < 0.0001), GSK458 cost duodenitis (χ2 = 6.308, P = 0.012) and chronic gastritis (χ2 = 18.673, P = 0.000), while there is no relationship between gastric body cracks and atrophy, intestinal metaplasia, atypical hyperplasia, gastric ulcer and esophagitis (P > 0.05). Conclusion: The cracking appearance in the gastric body suggests severe inflammation and relates with H. pylori infection. It is thus recommended that for patients with gastric body cracks but RUT negative, pathological examination of H. pylori should be done in both gastric antrum and body
in order to increase the detection rate. Key Word(s): 1. Gastric body; 2. cracking appearance; 3. H. pylori infection; 4. patho-histology; Presenting Author: YONG XIE Additional Authors: ZHIFA LV, BEN WANG, HUILIE ZHENG Corresponding Author: YONG XIE Affiliations: the First Affiliated Hospital of Nanchang University; Medical College of selleck kinase inhibitor Nanchang University; Public Health College of Nanchang University Objective: Several studies have reported that the application of probiotics during the eradication of H.pylori can improve the eradication rates and reduce the therapy-associated side. To determine whether the probiotics could help to improve the eradication rates and reduce side effects, and to investigate the appropriate time to add the probiotics during anti-H. pylori treatment. Methods: By searching PUBMED, EMBASE, SCI, CKNI and Wanfang Databases, we selected all the randomized controlled trials (RCTs) comparing probiotics supplementation to placebo or no treatment during anti-H. Pylori regimens for meta analysis.