Nucleic Acids Res 2009, (37 Database):D26–31 54 Krogh A, Larsso

Nucleic Acids Res 2009, (37 Database):D26–31. 54. Krogh A, Larsson B, von Heijne G, Sonnhammer MEK inhibitor drugs EL: Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 2001,305(3):567–580.CrossRefPubMed

55. Sandu C, Chiribau CB, Sachelaru P, Brandsch R: Plasmids for nicotine-dependent and -independent gene expression in Arthrobacter nicotinovorans and other Arthrobacter species. Appl Environ Microbiol 2005,71(12):8920–8924.CrossRefPubMed 56. Gartemann KH, Eichenlaub R: Isolation and characterization of IS an insertion element of 4-chlorobenzoate-degrading Arthrobacter sp. strain TM1, and development of a system for transposon mutagenesis. J Bacteriol 1409,183(12):3729–3736.CrossRef

57. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol p38 MAPK pathway reagent. J Biol Chem 1951,193(1):265–275.PubMed 58. Branco R, Chung AP, Morais PV: Sequencing and expression of two arsenic resistance operons with different functions in the highly arsenic-resistant strain Ochrobactrum tritici SCII24T. BMC Microbiol 2008, 8:95.CrossRefPubMed Authors’ contributions KH conceived and carried out the molecular genetic, gene expression and growth studies and performed the majority of manuscript writing. CN Vorinostat mouse participated in study design and coordination, performed sequence analysis of the chromate efflux gene,

alignment of chromate efflux amino acid sequences and generated the phylogenetic trees. DT participated in study design and coordination. heptaminol AK participated in study design and coordination. All authors participated in drafting the manuscript. All authors read and approved the final manuscript.”
“Background Several bacteria utilize a cell-cell communication system called quorum sensing to coordinate diverse behaviors in response to population density [1]. This quorum sensing process is based on the generation of small signaling molecules by means of specific synthases. These signaling molecules accumulate into the extracellular environment and when a certain threshold concentration is reached, the bacteria detect and respond to this signal by altering their gene expression. Although several quorum sensing systems are known, the synthase highly conserved in many both Gram-negative and Gram-positive bacterial species is the quorum sensing synthase LuxS [2, 3]. This enzyme catalyzes the conversion of S-ribosylhomocysteine to 4,5-dihydroxy-2,3-pentanedione (DPD) and homocysteine [4]. The unstable DPD spontaneously cyclizes into a family of interconverting molecules, collectively referred to as autoinducer-2 (AI-2) [5]. One of the first species reported to produce and respond to AI-2 resulting in expression of its luminescence genes is the marine pathogen Vibrio harveyi [6].

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