We then changed the scope to PCF-PQ260L (Olympus) with passive bending function and is 1680 mm in length, because using this endoscope, insertion to the third portion

of duodenum or even beyond the ligament of Treitz is relatively easy. A transparent cap was also attached on the tip of the endoscope. Pulsatile bleeding vessel in a diverticulum at the third portion of duodenum Daporinad chemical structure was recognized, and endoscopic hemostasis was successfully performed with argon plasma coagulation. We re-started the antithrombotic medication on the third hospital day. She discharged our hospital without re-bleeding on the sixth hospital day. Conclusion: Thus, a long scope with passive bending function is suggested to be useful for endoscopic hemostasis for diverticular bleeding at the third portion of duodenum. Key Word(s): 1. duodenal diverticulum bleeding Presenting Author: LIANG ZHU Additional Authors: YUNHONG WU, DEZHENG GONG, QIJING WANG, SHUHAO ZHANG, ZIHANG HUANG, LIHONG CHEN, CHUNYANG SUN, LILI GUAN, BO YAUN, DEQIN

YU, JINGZHOU MU, QIUYU CHEN, SHUPING LIU, YUFEI ZHAO, YUAN ZOU Corresponding Author: LIANG ZHU Affiliations: selleckchem Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Dalian Medical University, Teicoplanin Dalian Medical University, Dalian Medical University, Dalian Medical University Objective: To evaluate the protective effect

of GLP-2 on intestinal barrier function of stress ulcer rat. Methods: 20 SD rats with similar weight were randomly divided into two groups, the GLP-2 group (Group C), and the control group (Group D), with 10 rats in each group. GLP-2 was dissolved in sterile PBS buffer (0.01 mol/ L, 20 μg/ml, pH7.0), and subcutaneously injected at the dose of 250 μg/kg/d, for 2 times with an interval of 12 hours. The administration continued for 3 days. The control group was injected of the corresponding volume of PBS. Water-immersion and restraint stress (WRS) was used to duplicate stress ulcer (SU) model. Techniques including pathology, immunohistochemistry and bacterial culture were applied to observe the effect of GLP-2 on rat intestinal barrier function in stress ulcer. Results: In stress ulcer rat received GLP-2, the villous height and crypt depth of the jejunum, ileum and colon were observed, and the expression of Inos, NF-κB was decreased, but occludin-1, PCNA was increased. The bacterial translocation to mesenteric lymph nodes was also obviously inhibited by GLP-2. Conclusion: GLP-2 is effective to stimulate the proliferation and improve the barrier function of rat intestinal mucous membrane in stress ulcer. Supported by the National Nature Science Foundation of China No. 81370583, No. 30801127; Liaoning BaiQianWan Talents Program No.