We report a case in which a sporadic adenocarcinoma that occurred on the lymphomatous polyp of colon was successfully resected using endoscopic submucosal dissection (ESD) technique. Methods: A 69-year-old female presented with abdominal discomfort and intermittent
anal bleeding for 3 months. Under the colonoscopy, PF-562271 research buy there are numerous non-epithelial polyps with various sizes in the colon and an epithelial neoplasm larger than 4 cm in the ascending colon. The biopsy of a non-epithelial polyp showed focal nodular lymphoid hyperplasia, and the biopsy of the epithelial neoplasm revealed tubular adenoma with low grade dysplasia. A computed tomography demonstrated multiple tiny mural nodules in the colon and multiple homogeneous attenuated lymph node enlargement in Lt. gastric, para-aortic, aortocaval, ileocolic, mesenteric area. Results: About 4.5 cm sized epithelial neoplasm in the ascending colon was completely resected using ESD technique. The ESD specimen showed intraepithelial well-differentiated adenocarcinoma and extranodal marginal zone B-cell lymphoma (MALT lymphoma). About 0.5 cm sized non-epithelial polyp was resected using endoscopic mucosal resection (EMR) technique. The EMR specimen revealed diffused large B-cell lymphoma that may arise from MALT lymphoma. She was
treated with R-CHOP chemotherapy. Conclusion: We report a check details rare Etoposide cost case of synchronous multiple lymphomatous polyposis and adenocarcinoma in the colon. Key Word(s): 1. multiple lymphomatous polyposis; 2. adenocarcinoma; 3. colon Presenting Author: SOO-CHEON CHAE Additional Authors: J. MO, K. ALAM, S. CHOI Corresponding Author: SOO-CHEON CHAE Affiliations: School of Medicine, Wonkwang University, School of Medicine, Wonkwang University, School of Medicine, Wonkwang University Objective: MicroRNAs (miRNAs) are small non-coding RNAs which down-regulate gene expression of protein-coding genes by either translational
repression or mRNA degradation. The present study aimed to investigate the miRNAs associated with the pathogenesis of colon cancer, and to identify their target genes. Methods: The candidate miRNAs were extracted and isolated by analysis of the miRNA microarray chips results between colon cancer and normal colon. The expression levels of differentially expressed miRNAs using quantitative real-time polymerase chain reaction (RT-qPCR) was validated. Results: One of them, miR375 was detected as lower expression level in colon cancer than normal colon tissue. The miR375 targets were predicted using the mRNA microarray analysis of the human colon cell lines, Caco2 and SW480, between the normal cells and the candidate miRNA over-expressed cells. The several candidate target genes for MIR375 were identified and validated.