“
“We describe here a novel hybrid organic/inorganic nanocomposite of hexahexyloxytriphenylene (HAT6) which is a columnar discotic liquid crystal and gold tetrachloride, an inorganic dopant. showing enhanced dc and JNJ-26481585 datasheet ac electrical conductivity by several orders of magnitude at ambient conditions vis-a-vis the respective pure components. The composites at appropriate concentrations of the dopants retain the columnar hexagonal phase, which is confirmed by polarizing

optical microscopy, differential scanning calorimetry, and x-ray scattering techniques. The UV-vis spectral studies show that the composites absorb in the entire visible range due to the formation of radical cations of the discotic molecules. making it a potential candidate for solar cell applications. (C) 2009 American Institute of CP-456773 manufacturer Physics. [doi: 10.1063/1.3248342]“
“Aim:

To discuss the management

of the uncommon situation of metastatic gastrointestinal tumour coexisting with pregnancy.

Method:

We describe two cases of women with metastatic gastrointestinal stromal tumor (GIST) who successfully achieved a full-term pregnancy without complications and with the delivery of healthy infants. In both cases, treatment with imatinib mesylate was withheld during pregnancy because of its unknown effects and questionable safety for the developing fetus. The available data in the medical literature regarding the use and safety of imatinib and pregnancy are reviewed. We also examine whether the knowledge of the exon mutational status would have influenced treatment decisions.

Results:

Both women had wild type GIST, but with different tumor growth characteristics,

treatment responses and outcomes. The first patient deferred imatinib therapy to fall pregnant and her disease progressed rapidly off treatment. The second patient had a more indolent GIST where active surgical management allowed her to experience a long durable clinical response. She potentially belongs to a pediatric subgroup which carries a LOXO-101 better prognosis despite being off imatinib.

Conclusion:

While we have successfully managed two pregnant women with metastatic GIST, the issue of initiating imatinib therapy in treatment-naive women, and treatment interruption in women already on therapy, remain difficult areas. Patients and their partners need to make an informed choice regarding the associated risks and the potential long-term sequelae if pregnancies are contemplated. Further research into the natural history of wild type GIST and how to tailor subsequent treatment are needed.”
“We have studied the effects of hydrostatic pressure on the electrical transport and magnetic properties of La1.32Sr1.68Mn2O7 layered manganite up to 25 kbars. At ambient pressure, the Compound exhibits a ferromagnetic transition accompanied by a metal-insulator transition (T-MI(1)) at 1.18 K.