(The Journal of Neuropsychiatry and Clinical Neurosciences 2011; 23:391-398)”
“The present study investigated the effects of the multikinase inhibitor sorafenib on androgen-independent cancer cells viability and intracellular signaling. Human androgen-independent PC-3 prostate cancer cells were treated with sorafenib. At concentration that suppresses extracellular signal-regulated kinase phosphorylation, sorafenib treatment reduced the A-1331852 supplier mitochondrial transmembrane potential. Sorafenib also down-modulated the levels of myeloid cell leukemia 1, survivin and cellular inhibitor of
apoptosis protein 2. Sorafenib induced caspase-3 cleavage and the mitochondrial release of cytochrome c. However, no nuclear translocation of apoptosis inducing factor was detected after treatment and the pan-caspase inhibitor Z-VAD-FMK had an obvious protective effect against the drug. In conclusion, sorafenib induces apoptosis through a caspase-dependent mechanism with down-regulated antiapoptotic proteins in androgen-independent prostate cancer cells in vitro.”
study of BaTiO3 nanoparticles doped with different transition metals including Co, Fe, and Cr is presented. X-ray diffraction and electron microscopy studies indicated that all the samples are highly crystalline and that transition metal dopants are successfully learn more incorporated into BaTiO3 without detectable secondary phases. Raman spectra featured three characteristic broad bands centered approximately 300, 520, and 715 cm(-1) from the tetragonal BaTiO3 without any extra peak present that may be attributed to other impurity phases. Temperature-and field-dependent magnetometry measurements and analysis revealed that all the samples show paramagnetic-like behavior originating from the transition metal ions. These
results not only allow the exclusion of potential secondary ferromagnetic or antiferromagnetic phases, but also suggest that transition metal ions (Co, Cr, and Fe) in BaTiO3 click here shown in this study are present as isolated paramagnetic centers. (C) 2011 American Institute of Physics. [doi:10.1063/1.3556768]“
“Depression is common in Huntington’s disease, but standard rating scales have doubtful validity in this population. Using data from the European Huntington’s Disease REGISTRY study, the authors examined the discriminant value of items on the Beck Depression Inventory (N=843) and the Hamilton Rating Scale for Depression (N=768). Good discriminators of depression, apart from “”depressed mood,”" were “”guilt,”" “”loss of interest,”" and “”suicidality.”" Items that discriminated poorly were “”weight loss,”" “”sleep disturbance,”" “”loss of appetite,”" “”psychomotor retardation,,”" “”agitation,”" and “”irritability.