The groups were well balanced by Child-Pugh, UNOS, and BCLC, with older age in the 90Y cohort (P < 0.001). Findings included fewer transaminase elevations, a strong trend for better response (90Y: 49%; TACE: 36%; P = 0.052) selleck chemicals and longer TTP with 90Y (90Y: 13.3 months; TACE: 8.4 months; P = 0.046). However, no survival difference could be identified

(90Y: 20.5 months; TACE: 17.4 months; P = 0.232). Several important conclusions were drawn from this analysis. First, although there was no survival difference, radioembolization (outpatient procedure) was able to provide better disease control (longer TTP) with less toxicity than TACE (inpatient procedure). Second, although TTP has been suggested as a potential surrogate of survival, this study did not seem to provide compelling evidence in support of this contention. Finally, given the similarity of long-term survival outcomes, the findings brought into question the feasibility of a head-to-head comparative study between 90Y and TACE, requiring a 1,000-patient sample to demonstrate equivalence. Given the advent of sorafenib as the standard of care for patients progressing beyond intermediate disease, the feasibility of a statistically pure head-to-head (without crossover) comparison appears unlikely.[38] Hence, most investigators have begun to recognize 90Y for more

advanced BCLC B/early BCLC C disease, because the secondary benefits of 90Y, including clinical toxicities, quality of life, days RVX-208 hospitalized, and cost-effectiveness, Carfilzomib ic50 have been explored through feasibility studies. Most recently, in 2012, the Milan-INT group presented the first, prospective phase II study powered to investigate 90Y in 52 patients with intermediate or advanced HCC.[33] Findings included a TTP of 11 months and survival of 15 months. Some patients were downstaged to resection despite advanced stage. Furthermore, survival of PVT patients did not differ from intermediate (non-PVT) patients. This study further validated the reproducibility of 90Y under controlled investigations

and reconfirmed survival outcomes in patients with well-preserved liver function and vascular invasion. Given the lack of compelling clinical evidence supporting the TACE plus sorafenib combination (SPACE study abstract, press release), recent interest in combining 90Y with sorafenib has been reconsidered and subsequently catalyzed the development of head-to-head and combination studies with sorafenib in patients with PVT. There continues to be growing clinical interest in 90Y as a treatment modality for HCC. However, one of the ongoing controversies has been challenging the level of evidence with 90Y (no RCTs) and a thorough discussion of what would be required for 90Y incorporation into treatment guidelines. Although the European Society of Medical Oncology and the National Comprehensive Cancer Networks have recognized 90Y as a treatment option, the American and European Associations for the Study of the Liver have not.