PubMedCentralPubMed 51. Bonifait L, Grignon L, Grenier D: Fibrinogen induces biofilm formation by Streptococcus suis and enhances its antibiotic resistance. Appl Environ Microbiol 2008, 74:4969–4972.PubMedCentralPubMedCrossRef 52. Olson ME, Ceri H, Morck DW, Buret AG, Read RR: Biofilm bacteria: formation and comparative susceptibility to antibiotics. Can J Vet Res 2002, 66:86–92.PubMedCentralPubMed 53. Brisebois LM, Charlebois R, Higgins R, Nadeau M:

Prevalence of Streptococcus suis in four to eight week old clinically healthy piglets. Can J Vet Res 1990, APO866 chemical structure 54:174–177.PubMedCentralPubMed 54. MacInnes JI, Gottschalk M, Lone AG, Metcalf DS, Ojha S, Rosendal T, Watson SB, Friendship RM: Prevalence of Actinobacillus pleuropneumoniae , Actinobacillus suis , Haemophilus parasuis , Pasteurella multocida , and Streptococcus suis in representative Ontario swine herds. Can J Vet Res 2008, 72:242–248.PubMedCentralPubMed 55. Amass SF, Wu CC, Clark LK: Evaluation of antibiotics for the elimination of the tonsillar carrier state of Streptococcus suis in pigs. J Vet Diagn Invest 1996, 8:64–67.PubMedCrossRef 56. Smith HE, Veenbergen V, Van der Velde J, Damman M, Wisselink HJ, Smits MA: The cps

genes of Streptococcus suis serotypes 1, 2, and 9: development of rapid serotype-specific PCR assays. J Clin Microbiol 1999, 37:3146–3152.PubMedCentralPubMed Veliparib 57. Schubert A, Zakikhany K, Schreiner M, Frank R, Spellerberg B, Eikmanns BJ, Reinscheid DJ: A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand binding sites. Mol Microbiol 2002, 46:557–569.PubMedCrossRef 58. Rohde M, Muller E, Chhatwal GS, Talay SR: Host cell caveolae act as an entry-port for group A streptococci. Cell Microbiol 2003, 5:323–342.PubMedCrossRef

59. Molinari G, Talay SR, Valentin-Weigand P, Rohde M, Chhatwal GS: The fibronectin-binding protein of Streptococcus pyogenes , SfbI, is involved in the internalization of group A streptococci by epithelial cells. Infect Immun 1997, 65:1357–1363.PubMedCentralPubMed Orotic acid Competing interests The authors declare that they have no competing interests. Authors’ contributions JW and DW carried out the experiments and analyzed the data. RB helped with the design of the study and draft of the manuscript. JW, RG and PVW conceived the study, participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Background Acinetobacter baumannii has emerged as a major cause of nosocomial infections, especially in intensive care units [1]. Both its ability to acquire resistant determinants and to adapt to harsh environments has made A. baumannii a successful pathogen [2]. A. baumannii has high rates of resistance to many available antibiotics in clinical practice. For example, imipenem-resistant A. baumannii constituted > 50% of a worldwide collection of clinical samples between 2005 and 2009 [3].