\n\nPredictor: Older age, defined as 65 years or older, and antineutrophil cytoplasmic antibody, detected using immunofluorescence and enzyme-linked immunosorbent assay, at presentation.\n\nOutcomes: Clinical features, kidney pathologic characteristics, end-stage renal disease (ESRD), and mortality. Multivariate Cox proportional Taselisib order hazard models were used to assess the contribution of age, sex, clinical measures, and treatments to ESRD and mortality.\n\nResults:
50 of 221 (22.6%) patients were 65 years or older. Older patients had a male predominance (male/female ratio, 1.9:1). They had a higher proportion of positive antineutrophil cytoplasmic antibody results (46.0% vs 14.6%; P < 0.001), lower prevalence of hemoptysis (26.0% vs 46.2%; P = 0.01), lower urine protein excretion (1.4 +/- 1.0 vs 3.9 +/- 3.3 g/d; P = 0.001), and higher estimated glomerular filtration rate (eGFR) at presentation (8.4 vs 5.1 mL/min/1.73 m(2); P = 0.007) compared with younger patients. During follow-up, 30 of 37 (81.1%) and 21 of 37 (56.8%) patients developed ESRD and died in the older group compared with 115 of 139 (82.7%) and 35 of 139 (25.2%) in the younger group (P = 0.1 and P
= 0.001, respectively). For older patients, multivariate click here Cox regression analysis showed that higher initial eGFR was an independent predictor for both ESRD (HR, 0.86; 95% CI, 0.78-0.96; P = 0.005) and death (HR, 0.79; 95% CI, 0.66-0.94; P = 0.008).\n\nLimitations: Not all patients underwent kidney biopsy, especially those with very old age or ESRD P005091 datasheet at presentation.\n\nConclusions: Older patients with anti-GBM disease had milder kidney damage and less pulmonary
involvement. Outcomes were predicted by initial eGFR. Thus, early diagnosis was crucial to improve outcomes. Am J Kidney Dis. 57(4):575-582. (C) 2011 by the National Kidney Foundation, Inc.”
“We found the prevalence of recurrent lymphocytic meningitis associated with herpes simplex virus type 2 (HSV-2) was 2.2/100,000 population in Finland during 1996-2006, higher than previous estimates. PCR was most sensitive in detecting HSV-2 DNA from cerebrospinal fluid if the sample was taken 2-5 days after symptom onset.”
“The description of the frog “Hyla” antoniiochoai is based on a subadult female and a juvenile collected in 2005 near Esperanza, Kosnipata Valley, Region (formerly Departamento) Cusco, southeastern Peru. The species was assigned to the genus Hyla (Hylidae) but could not be assigned to any species group within this genus. According to the original description, typical characters include the absence of webbing in hands, and vestigial webbing between Toes III and IV. In 2009, we collected additional specimens including adults of both sexes from the type locality. To our surprise these specimens show characters, such as a closed brood pouch, that are typical of Gastrotheca (Hemiphractidae).