Patients had an ECOG performance
of 0-2, and Stage III and IV disease. Both untreated and previously treated patients with progressive disease were eligible. Patients received a combination of rituximab 375 mg/m(2), Cyclophosphamide 1000 mg/m(2), and vincristine 1.4 mg/m(2) (up to a maximal dose of 2 mg), administered by intravenous infusion every two weeks, for ten treatments. Prednisone 50 mg was administered every other day orally for thirty days and then tapered over the next thirty days. Granulocyte colony stimulating factor (G-CSF) was administered on days seven to ten following each cycle of chemotherapy. After 5 and 10 cycles, patients were evaluated for response LM-1149 that included imaging with CT and PET scans. A total of 10 patients (7 untreated and 3 previously treated) were enrolled into this pilot study between May 2003 and July 2004. Untreated patients received an average of 8.3 cycles of therapy (range 5 to 10 cycles). Seven of 7 untreated patients achieved a complete
response (CR), and 5 had not relapsed as of 32-43 months later. Previously treated patients received an average of 9.3 cycles of therapy (range 6 to 12 cycles). One of three previously treated patients achieved a complete response and has no evidence of relapse at 29 months. The other TH-302 clinical trial two heavily pretreated patients achieved partial responses, lasting 2 and 5 months. Toxicity was mild consisting mainly of parasthesias requiring attenuation of the vincristine dose. There were no instances of neutropenic fever check details requiring hospitalization. This program is well tolerated with a high CR rate, and may serve as a basis for future trials.”
“Objective: To determine whether parents understand and adhere to preoperative fasting instructions. Aim: To identify how we may reduce perioperative morbidity relating to failure to fast. Background: Children are routinely fasted preoperatively with the aim of reducing the risk of aspiration of gastric contents and its sequelae. Methods: Parents of children on the day case ward following elective surgery completed a survey asking:
(i) For how long was your child asked to fast? (ii) How long did you ensure your child was fasted of food and clear fluids? (iii) What do you think is the purpose of fasting? We also asked the parents to complete a checklist of items they thought acceptable to consume when fasting. Results: Despite affirming fasting status in the preoperative check, 13.5% were not fasted. Parents reported advised fasting times of 124 h (median 6) for solids and 0.524 h (median 3) for fluids. Children were fasted of solids for 340 h (median 9.5) and of fluids for 0.524 h (median 5). Regarding the understanding of fasting, 9 referred to aspiration and 53 to the prevention of nausea or vomiting. Thirteen believed that fasting status altered the efficacy of anesthesia. During the fasting period, 4.9% would allow French fries, 22.3% toast/crackers, 17.5% cereal, 14.7% a sweet, 14.