good candidates for research would be the superfamily of the cytochromes P450 and the group of glutathione S transferases. COX 2 inhibitors may possibly produce their effects determined by or independent of the COX 2 enzyme. Evidence we obtained have been in favor of an off target effect. We demonstrate here that the low basal PGE2 generation in U937 cells, our key cell model, isn’t modulated by the incubation with COX 2 inhibitors, even when they’re used at very high concentrations, furthermore, the non energetic analog of celecoxib, 2,5 dimethyl celecoxib, is similarly in a position to protect cells against apoptosis. The anti apoptotic potential of COX 2 inhibitors isn’t limited to a certain cell type, because different hematopoietic cancer cell models look similarly modulated. The section of selected hematopoietic cell lines Pemirolast dissolve solubility examined is heterogeneous for biological traits along with for COX 2 protein expression. The fact that COX 2 inhibitors, nevertheless, generally fight apoptosis supports our proof that the phenomenon is unrelated to COX 2 enzyme inhibition. Besides, it shows that the anti apoptotic potential of COX 2 inhibitors is huge, nevertheless the current insufficient a general goal makes also impossible to predict which cells may be largely vulnerable. An extremely recent study showed an ability of celecoxib to downregulate an importer particular for cisplatin in an adherent cancer cell type. Taken together, other results and our encourage speculation that COX 2 inhibitors, Endosymbiotic theory versus previous studies, may possibly exert anti apoptotic consequences in a heterogeneous and large number of cancers where the exacerbation of varied chemoresistance related phenomena plays a determining role. The mean blood concentration of nimesulide is estimated as 20 mM after administration of 100 mg nimesulide, with mountains of 37. 6 mM after 1 week of therapy. These values make reference to the consumption of the compound for antiinflammatory applications taking into consideration the plasma proteins binding. Nevertheless, at the sites of irritation the effective focus natural product library is expected to be greater, as seen for other compounds usually bound by albumin, due to the lower pH. Within our arms, the anti apoptotic effect of nimesulide is significant from a concentration of 10 mM, thus in the number of therapeutic levels. Subjects subjected to chemotherapeutic protocols an average of build inflammatory conditions as a consequence of macrophage engulfment. Ergo, it is conceivable that the effective concentration of the compounds in the tumor microenvironment may even be higher. Besides, various COX 2 inhibitors are under study for anti cancer methods. In cases like this, the management of higher levels is under evaluation.