Genotoxic

agents may cause severe, well-known, allergic IgE-mediated reactions, in particular Platinum agents but also antibiotics. These can also lead to alopecia, because of their targeting on proliferating cells, and particular effects like erythema flagellatum whose pathogenesis is unknown. Multikinase inhibitors used in hematology like Imatinib, Dasatinib and Nilotinib seem to be connected to frequent skin toxicity mainly consisting of dermatitis, sometimes exfoliative, associated with fever [1] and frequently with edema. Sorafenib and Sunitinib are BTSA1 datasheet two other multikinase inhibitors used for kidney and liver cancer. Inflammatory actinic keratosis has also been observed [13, 14]. Sunitinib is associated to bullous manifestation and hand-foot syndrome, which can also be used as a marker of drug efficacy [15]. Conclusions New drugs and new therapeutic schedules have brought many malignancies to a better prognosis and a longer survival. However newer drugs, in particular targeted therapies, often provoke side effects on the skin, obliging physicians to suspend therapy. For this reason the challenge

of future studies in this field is to identify methods capable to prevent this kind of side effects and, at the same time, specific therapies for each skin problem. Cooperation between oncologists and dermatologists is also fundamental in order to make the best decisions

Napabucasin for Sorafenib concentration the patients and to implement preventive measures. Electronic supplementary material Additional file 1: EGFR-inhibitors skin toxicities. (PNG 21 KB) Additional file 2: Compared frequency of skin adverse reactions among different group of drugs. (PNG 26 KB) Additional file 3: Hormonal therapy skin adverse reactions. (PNG 22 KB) Additional file 4: Traditional drugs skin toxicities. (PNG 20 KB) References 1. Noushin H, Haley N, Susan B: Chemiotheraputic agents and the skin: an update. J Am Acad Dermatol 2008, 58:545–570.CrossRef 2. Tianhong L, Roman P: Skin toxicities associated with epidermal growth factor receptor inhibitors. Targ Oncol 2009, 4:107–119.CrossRef 3. Galimont-Collen AFS, Vos LE, Lavrijsen APM, Ouwerkerkb J, Gelderblomb H: Classification and management of skin, hair and nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors. Eur J VX-770 concentration cancer 2007, 43:845–851.PubMedCrossRef 4. Jatoi A, Nguyen PL: Do patients die from rashes from epidermal growth factor receptor inhibitors? A systematic review to help counsel patients about holding therapy. Oncologist 2008, 13:1201–1204.PubMedCrossRef 5. Wagner LI, Lacouture ME: Dermatologic toxicities associated with EGFR inhibitors: the clinical psychologist’s perspective.