Extremes are generally described by exceedance events   which are events which occur when some variable exceeds a given level. Two statistics Compound C clinical trial are conventionally used to describe the likelihood of extreme events such as flooding from the ocean. These are the

average recurrence interval   (or ARI  ), R  , and the exceedance probability  , E  , for a given period, T  . The ARI is the average period between extreme events (observed over a long period with many events), while the exceedance probability is the probability of at least one exceedance event happening during the period T  . Exceedance distributions are often expressed in terms of the cumulative distribution function  , F  , where F=1−EF=1−E. F is just the probability

that there will be no exceedances during the prescribed period, T. These statistics are related by (e.g. Pugh, 1996) equation(1) F=1−E=exp−TR=exp(−N)where N is the expected, or average, number of exceedances during the period T. Eq. (1) involves the assumption (made throughout this paper) that exceedance events are independent; their occurrence therefore follows a Poisson distribution. This requires a further assumption about the relevant time scale of an event. If multiple closely spaced events have a single cause (e.g. flooding events caused by one particular storm), they are generally combined into

a single event using a declustering algorithm. The occurrence of sea-level extremes, and therefore, the buy Tyrosine Kinase Inhibitor Library ARI and the exceedance probability, will be modified by sea-level rise, the future of which has considerable uncertainty. For example, the projected sea-level rise for 2090–2099 relative to 1980–1999, for the A1FI emission scenario (which the world is broadly following at present; Le Quéré et al., 2009), is 0.50±0.26 m (5–95% range, including scaled-up ice sheet discharge; Meehl et al., 2007), the range being larger than the central value. The expected number of exceedances above a given level and over a given period may, in general, be described by equation(2) Montelukast Sodium N=Nμ−zPλwhere NN is some general dimensionless function, z  P is the physical height (e.g. the height of a critical part of the asset), μμ is a ‘location parameter’ and λλ is a ‘scale parameter’. As noted in Section 1, it is assumed that there is no change in the variability of the extremes, which implies that the scale parameter, λλ, does not change with a rise in sea level. Mean sea level is now raised by an amount Δz+z′Δz+z′, where ΔzΔz is the central value of the estimated rise and z′z′ is a random variable with zero mean and a distribution function, P(z′)P(z′), to be chosen below. This effectively increases the location parameter, μμ, by Δz+z′Δz+z′.