e. once every 12 hours). Although care must be taken with concomitant use of AEDs that act on sodium channels, adjunctive therapy with lacosamide (a non-traditional sodium-channel blocking AED) significantly check details reduced seizure frequency regardless

of co-administration of traditional sodium-channel blockers in this open-label trial.[19] Randomized controlled trials of lacosamide are needed to confirm and validate the efficacy and safety results observed here in this pediatric population. Acknowledgments This study was funded by Dr. Carlos Casas-Fernández. Medical writing and journal styling assistance was provided by Maxwell Chang and Lucy Whitehouse, and post-submission writing assistance was provided by Tracy Harrison, all of inScience Communications, Springer Healthcare; this assistance was funded by Dr. Carlos Casas-Fernández, The authors have no conflicts of interest to declare. The authors confirm that they have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. Appendix:

Lacosamide Spanish Study Group Members Dr. Alarcón-Martínez (Hospital Universitario Virgen de la Arrixaca, Murcia); Dr. Arrabal-Fernández (Hospital Universitario Virgen de las Nieves, Granada); Dr. Cabrera-López (Hospital Universitario Materno-Infantil, Las Palmas de Gran Canaria, Canary Islands): Dr. Camino-León (Hospital Universitario

Reina Sofía, Cordoba); Dr. Campistol-Plana (Hospital Universitario San Juan de Dios, Barcelona); Dr. Campos-Castello (Hospital Clínico Adenosine San Carlos, Madrid); Dr. see more Casas-Fernández (Hospital Universitario Virgen de la Arrixaca, Murcia); Dr. Domingo Jiménez (Hospital Universitario Virgen de la Arrixaca, Murcia); Dr. Duque-Fernández (Hospital Universitario Virgen de La Candelaria, Santa Cruz de Tenerife); Dr. Eiris-Puñal (Hospital Clínico Universitario, Santiago de Compostela); Dr. García-Peñas (Hospital Universitario Marqués de Valdecilla, Santander); Dr. Herranz-Fernández (Universidad de Cantabria, Santander); Dr. Ibáñez-Micó (Hospital Universitario Virgen de la Arrixaca, Murcia); Dr. Jover-Cerda (Hospital General de Elda, Alicante); Dr. Lara-Herguedas (Hospital Universitario Puerta de Hierro-Majadahonda, Madrid); Dr. López-Lafuente (Hospital San Pedro de Alcántara, Cáceres); Dr. Madruga-Garrido (Hospital Universitario Virgen del Rocío, Seville); Dr. Martínez-Bermejo (Hospital Universitario La Paz, Madrid); Dr. Martínez-Salcedo (Hospital Universitario Virgen de la Arrixaca, Murcia); Dr. Puche-Mira (Hospital Universitario Virgen de la Arrixaca, Murcia); Dr. Roldán-Aparicio (Hospital Universitario Virgen de las Nieves, Granada); Dr. Rufo-Campos (Instituto Hispalense de Pediatría, Seville); Dr. Santos-Borbujo (Hospital Clínico Universitario, Salamanca); Dr.