All patients consented to genetic investigation for IL-28B genetic variants at rs8099917. Seven patients had genotype TT, 9 patients had genotype TG, and

no patients had genotype GG at rs8099917. Results: In 5 (4 from the relapse group and 1 from the break-through group) of 16 patients, serum levels of HCV-RNA quantified by RT-PCR decreased constantly; 3 had the TT genotype and 2 had the TG genotype. In 4 (3 from the relapse group and 1 from the break-through group) of 5 patients, serum HCV-RNA subsequently became undetectable; 2 had the TT genotype and 2 had the TG genotype. Levels of serum transaminases remained within normal limits in 5 patients (4 belonged to the relapse group and 1 to the break-through group); Epacadostat Trichostatin A chemical structure 3 had the TT genotype and 2 had the TG genotype. Conclusion: Although patients who failed to obtain SVR by PEG-IFN plus RBV combination therapy should be administered a new triple therapy, administration of 90 μg PEG-IFN-alpha 2a every 2 weeks is thought to be useful for patients who cannot receive the new triple therapy for some reason such as aging or anemia, even if relapse or break-through occurred prior to PEG-IFN plus

RBV combination therapy irrespective of their IL-28 genotypes at rs8099917. Key Word(s): 1. chronic hepatitis C Presenting Author: HENDRA KONCORO Additional Authors: KETUT MARIADI, GDE SOMAYANA, GUSTI AGUNG SURYADARMA, NYOMAN PURWADI, DEWA NYOMAN WIBAWA Corresponding Author: HENDRA KONCORO Affiliations: Department of Internal Medicine, Division of Gastroenterohepatology, Udayana University/Sanglah Hospital, Denpasar Objective: Findings Interleukin-2 receptor of liver cirrhosis are usually accompanied with screening endoscopy for large esophageal varices (EV) that may benefit from prophylactic measures. The aim of this study was to identify whether Model

for End-stage Liver Disease (MELD) score, Child-Turcotte-Pugh (CTP) score, AST to platelet ratio index (APRI), FiB4 index, and laboratory tests could predict the presence of large EV among patients with liver cirrhosis in Sanglah Hospital Denpasar. Methods: A total of 90 hospitalized liver cirrhosis patients from September 2012 until March 2014 were restrospectively analyzed. Variables used in the analysis included age, sex, etiology of cirrhosis, CTP classification, MELD score, APRI, FiB4 index, platelet count, serum creatinine, and liver function tests. The presence of large EV was correlated with those characteristics. Univariate and multiple regression analysis were used to determine which factors may predict large EV. Results: Of ninety (90) patients enrolled, 66 were male (73.3%) and 24 were female (26.7%); majority with chronic hepatitis B. Sixty (66.7%) of the 90 patients were found to have large EV. The distribution of large EV according to CTP classification was as follows: A, 63.16%; B, 62.8% and C, 75%. Large EV was independently associated with total bilirubin higher than 1.9 mg/dL (p = 0.