(C) 2012 Elsevier B.V. All rights reserved.”
“P>Only 2 cases of Campylobacter bacteremia have been reported in Selleckchem Citarinostat renal transplant recipients, to our knowledge, with both resulting in significant morbidity and mortality. We present a case of a 56-year-old renal transplant recipient who presented with brief diarrheal illness followed by Campylobacter jejuni bacteremia. She remained asymptomatic for 5 days after initial presentation despite positive blood cultures. She was treated with levofloxacin for a total of 4 weeks and, fortunately, did not develop any complications. C. jejuni should be considered in the differential diagnosis
as a potential cause of bacteremia in immunosuppressed renal transplant patients presenting with diarrheal illness.”
“Background: Alzheimer’s selleck chemicals disease (AD) neuropathology likely begins decades before clinical symptoms are manifested. Investigations
on the early stages of the amyloid pathology are crucial for the discovery of diagnostic biomarkers or new therapeutic targets. Our transgenic (tg) animal models are most suitable to study early AD pathological events, as the pathology evolves in a well-staged manner, starting with intracellular A beta accumulation and ending with plaque deposition. Objective: To determine the occurrence of key inflammatory markers and to look for signs of nerve growth factor (NGF) dysmetabolism at preplaque and postplaque stages in tg models of AD-like amyloid pathology and in human AD brains. Methods: We used our own tg lines (mice and rat), high-quality human
brain material and applied neurochemical and immunohistochemical experimental approaches. Results: In both tg models, we observed an intracellular accumulation of oligomeric A beta in cortical and hippocampal pyramidal neurons. This coincided with an upregulation of key inflammatory markers (iNOS, MHCII, COX-2) and a recruitment of microglia towards A beta-burdened neurons. Using human AD brains, we showed alterations in the NGF metabolic pathway, which were mirrored in our tg rat model Selleck PFTα at early and late stages of amyloid plaque generation. Conclusion: A proinflammatory process and, consequently, the deregulation of the NGF metabolic pathway could be amongst the earliest pathological events in the progression of AD. Copyright (C) 2012 S. Karger AG, Basel”
“To prospectively evaluate the performance of virtual non-calcium (VNC) dual-energy CT (DECT) images for the demonstration of trauma-related abnormal marrow attenuation in collapsed and non-collapsed vertebral compression fractures (VCF) with MRI as a reference standard.
Twenty patients presenting with non-tumoral VCF were consecutively and prospectively included in this IRB-approved study, and underwent MRI and DECT of the spine. MR examination served as a reference standard.