5-Hydroxymaltol, 5-hydroxymethylfurfural, Z-ligustilide, and ferulic acid in aqueous extract of processed danggui (APD) were determined Selleck GSI-IX by HPLC while antihypertensive
effects were studied after oral administration of APD (50 and 100 mg/kg) for 3 days in spontaneously hypertensive rats (SHR). Compared with aqueous extract of danggui (AD), contents of ferulic acid and Z-ligustilide in APD were significantly decreased but 5-hydroxymaltol and 5-hydroxymethylfurfural were increased. APD could lower blood pressures, plasma renin activities, and angiotensin II levels of SHR, but AD failed to do those. APD exhibited hypotensive effects by regulating renin-angiotensin system and may warrant further evaluation as a potential antihypertensive
agent.”
“Four kinds of core-shell structure acrylic impact modifiers (AIMs) with different rubber crosslinking densities were synthesized. The effects of the rubber crosslinking density of the AIMs on the crack initiation and propagation resistance and the mechanical properties of the AIM/poly(methyl methacrylate) (PMMA) blends were investigated, and we found that the maximum stress intensity VX-661 factor, crack propagation energy, and Izod impact strength reached maximums when the appropriate rubber crosslinking density of AIM, 2.51 X 10(25) crosslinks/m(3), was adopted. Transmission electron microscopy photographs of the AIM/PMMA blends showed that the AIMs dispersed uniformly in the PMMA matrix. Meanwhile, through the AZD1480 analysis of optical photos and scanning electron microscopy of the impact fracture surface, we found that the deformation mechanism of the AIM/PMMA blends was local matrix shear yielding initiated by rubber particle cavitation of the AIM. The rubber of the AIM, whose crosslinking density was 2.51 x 10(25) crosslinks/m(3), was beneficial to the formation of intensive voids and initiated the local shear yielding of nearby modifiers of the PMMA matrix effectively in impact tests, which led to higher Izod impact strengths. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115: 2386-2393, 2010″
“PURPOSE: To compare the
susceptibility and efficacy of 3 fluoroquinolones, (levofloxacin, gatifloxacin, and moxifloxacin) in treating conjunctival bacteria in patients having ocular surgery.
SETTING: Osaka University Hospital, Osaka, and Tohoku University Hospital, Miyagi, Japan.
METHODS: Eyes of patients were examined preoperatively. Aerobic and anaerobic cultures were obtained from conjunctival swabs. The minimum inhibitory concentrations (MICs) of levofloxacin, gatifloxacin, and moxifloxacin for isolated strains were determined. Using the MIC values, descriptive statistics (median, MIC(50), MIC(90), mode, and range), susceptibility, and efficacy of each fluoroquinolone were calculated for the bacteria isolated, and the data were analyzed statistically.
RESULTS: Of the 200 eyes sampled, 163 (81.5%) had positive bacterial growth.