20 If numerous microarousals are detected, the upper airway resistance syndrome should be considered. A new sleep recording with esophageal pressure measures will be made to evaluate transpleural pressure. Personality tests are undertaken to exclude psychiatric hypersomnia, and cerebral imaging may be performed according to the clinical context. As no

animal model of idiopathic hypersomnia is available, pathophysiology of the sickness is speculative. Treatment of idiopathic hypersomnia uses a number of stimulant drugs, such as modafinil, Inhibitors,research,lifescience,medical which is often effective on excessive daytime sleepiness. However, sleep inertia persists in most cases. Small molecule library recurrent hypersomnia Recurrent hypersomnia is characterized by episodes of excessive sleep lasting from a few days to several weeks. Patients may sleep for at least 18 h a day, and Inhibitors,research,lifescience,medical rise only to eat and void. The episodes are typically separated by weeks or months, during which normal sleep patterns are resumed. Excessive sleep may accompany behavior abnormalities, such as overeating, sexual disinhibition, and other mental disturbances. This polysymptomatic form is represented by the Kleine-Levin syndrome which occurs in adolescent boys bearing the HLA DQB1*0201* type.24 The syndrome may also be idiopathic in relation to menstruation.25 It may even be Inhibitors,research,lifescience,medical secondary to neurological or psychiatric conditions, or a viral infection

that occurred weeks before. The diagnosis of Kleine-Levin syndrome is mainly clinical. Inhibitors,research,lifescience,medical Differential diagnosis must distinguish recurrent hypersomnia from obstructive sleep apnea syndrome, narcolepsy, or periodic limb

movement disorder. In order to confirm hypersomnia and exclude epilepsy and organic pathology, EEG and polysomnographic recordings, and cerebral imaging may prove useful. The etiology of idiopathic recurrent hypersomnia remains elusive, though most symptoms can be regarded as a hypothalamic dysfunction. Recurrent hypersomnia Inhibitors,research,lifescience,medical results in major disturbances in social and family life, and its prognosis is unknown. The evolution throughout life is favorable in most cases, with a progressive disappearance of symptoms. Treatment of recurrent hypersomnia episodes includes stimulants, despite their frequent lack of efficacy. Prophylactic measures may be successful, such as prevention with valproate, carbamazepine, or lithium carbonate,26 or estroprogestative ovulatory inhibitors in case of menstruation-related disturbances.25 Insufficient ADP ribosylation factor sleep syndrome The insufficient sleep syndrome is a disorder that occurs in an individual who fails to obtain sufficient nocturnal sleep to support normally alert wakefulness.8 The individual is in fact chronically sleep-deprived at his own will, without being aware of it. Such a situation is increasing in our modern technologically inclined societies. The individual is pressured by socioprofessional imperatives and feels that he or she does not have the time to do everything.