We used particle swarm optimization to optimize the ANN structure and initial weights (IW) for each patient and treatment fraction. Prediction accuracy is evaluated using the 1D superior-inferior lung-tumor motions of 29 lung cancer ABT-263 price patients for system delays of 120-520 ms, in increments
of 80 ms. The result is compared with four different scenarios: (1), (2) ANN structure optimization + with/without IW optimization, and (3), (4) no ANN structure optimization + with/without IW optimization, respectively. An additional simulation is performed to assess the value of optimizing the ANN structure for each treatment fraction.\n\nResults: For 120-520 ms system delays, mean RMSE values (ranges 0.0-2.8 mm from 29 patients) of 0.5-0.9 mm are observed, respectively. Using patient specific ANN structures, a 30%-60% decrease in mean RMSE values is observed as a result of IW optimization, alone. No significant advantages in prediction performance are observed, however, by optimizing for each fraction.\n\nConclusions: A new ANN-based lung-tumor motion predictor is developed for MRI-based intrafractional tumor tracking. The prediction accuracy of our predictor is evaluated using a realistic simulated MR imaging rate and system delays. For 120-520 ms system delays, mean RMSE values of 0.5-0.9 mm (ranges MLN4924 in vivo 0.0-2.8 mm from 29 patients) are achieved. Further, the advantage of patient specific
ANN structure and IW in lung-tumor motion prediction is demonstrated by a 30%-60% decrease in mean RMSE values. (C) 2012 American
Association of Physicists in Medicine. [http://dx.doi.org.library.tamiu.edu:2048/10.1118/1.4730294]“
“Echinacea purpurea is a widely used plant immunomodulator with a selective immunomodulatory effect depending on the dilution of the initial preparation. In low doses, it causes selective induction of pro- and anti-inflammatory cytokines. The results recommend this preparation in a wide range of concentrations for adequate correction of the immune system work aimed at restoring the Th1/Th2 balance in various diseases.”
“Background: Psychologically traumatic events can affect anybody, but consequences of psychological birth trauma for the mother are very profound, extensive Selleckchem STI571 and unforgettable. Furthermore, the mother’s response not only touches the mother, but also affects the child, the father and the society. The objective of this study was to explore the mothers’ response to psychological birth trauma.\n\nObjectives: Psychological birth trauma is a complex matter as the length of a women’s life and mother’s responds can be present through different psychological and physical ways. In this regard, the mothers suffer from its consequences, but they do not know what is going on? Mothers are getting worse every day by “the silent effects of the psychological phenomena.