Cross-sectional study University research laboratory Community-

Cross-sectional study. University research laboratory. Community-dwelling older women (n = 94, 73.6 +/- 5.4 y) stratified by BMI (normal weight: 20.0-24.9 kg/m(2); overweight: 25.0-29.9 kg/m(2); obese: a parts per thousand

yen 30.0 kg/m(2)). Body mass index using height and weight, leg extension power via the Nottingham power rig, body composition using dual-energy X-ray absorptiometry, and physical function (6-minute walk, 8-foot up-and-go, 30-second chair stand). Muscle quality was defined as leg power (watts) normalized for lower-body GSK1838705A solubility dmso mineral-free lean mass (kg). Following adjustments for covariates, muscle quality was significantly higher in women of normal BMI compared to overweight (10.0 +/- 0.4 vs 8.7 +/- 0.4 watts/kg, p = 0.03). Muscle quality was a significant

predictor of performance on the 6-minute walk and 8-foot up-and-go in normal and overweight women (all p smaller than 0.05) and performance on the 30-second chair stand in normal and obese women (both p smaller than 0.05). Body mass index did not significantly impact the association between MQ and physical function (all p bigger than 0.05). Muscle quality varies by BMI, yet the relationship to physical function is not significantly different across BMI groups. The results imply that interventions that increase MQ in older women may improve physical function, regardless of BMI.”
“The Model for End-Stage Liver Disease (MELD) score GNS-1480 ic50 has reduced predictive

ability in patients with cirrhosis and MELD scores smaller than = 20. We aimed to assess whether a 5-stage clinical model could identify liver transplantation (LT) candidates with low MELD scores who are at increased risk for death. We conducted a case-control study of subjects with cirrhosis and MELD scores smaller than = 20 who were awaiting LT at a single academic medical selleck products center between February 2002 and May 2011. Conditional logistic regression was used to evaluate the risk of liver-related death according to the cirrhosis stage. We identified 41 case subjects who died from liver-related causes with MELD scores smaller than = 20 within 90 days of death while they were waiting for LT. The cases were matched with up to 3 controls (66 controls in all) on the basis of the listing year, age, sex, liver disease etiology, presence of hepatocellular carcinoma, and MELD score. The cirrhosis stage was assessed for all subjects: (1) no varices or ascites, (2) varices, (3) variceal bleeding, (4) ascites, and (5) ascites and variceal bleeding. The MELD scores were similar for cases and controls. Clinical states contributing to death in cases were: sepsis 49%, spontaneous bacterial peritonitis 15%, variceal bleeding 24%, and hepatorenal syndrome 22%. In a univariate analysis, variceal bleeding [odds ratio (OR) 55.6, P = 0.003], albumin (OR = 0.

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