4% vs. 4.7%; p<0.007), but were less likely than pediatric patients to receive IV clindamycin (4.6% vs. 15.7%; p<0.001). Among discharged patients, trimethoprim-sulfamethoxazole (TMP-SMX), clindamycin, and cephalexin were kinase inhibitor Wortmannin prescribed commonly. 25.3% of all SSTI patients received an oral antibiotic in the ED, and 80.8% of patients discharged received an antibiotic Inhibitors,research,lifescience,medical prescription. Adult SSTI patients were more likely than

pediatric SSTI patients to be prescribed oral TMP-SMX (59.1% vs. 37.2%; p<0.001) at ED discharge. Of those prescribed TMP-SMX, adults were more likely than children to be also prescribed oral cephalexin (53.8% vs. 34.5%; p<0.001). Microbiologic data Table 2 summarizes the results of microbiologic cultures by age group among ED patients with cultured infections. S. aureus comprised the majority of culture isolates, and was more common in pediatric patients, Inhibitors,research,lifescience,medical while mixed flora was more common among adults than among children. Of

S. aureus isolated from CA-SSTIs, 60.4% was categorized as MRSA, with similar proportions in adults and children (60.9% vs. 59.2%; p<0.84). Table 2 Microbiologic culture results from emergency department (ED) Inhibitors,research,lifescience,medical patients with community-acquired skin & soft tissue infections Table 3 depicts the antibiotic susceptibilities among S. aureus isolated from presumed community-acquired purulent infections, comparing the resistance in these ED-acquired SSTI cultures against the resistance reported for MRSA and MSSA on the antibiogram distributed by the hospitals’ microbiology laboratory for S. aureus from all sources in 2010. Table 3 Antibiotic Resistance Among Staphylococcus Inhibitors,research,lifescience,medical aureus Isolated from skin and soft tissue

infections (SSTIs) in the emergency department Discordance of antibiotic therapy with culture results Table 4 compares antibiotic treatment with culture results among SSTIs for which both selleck chemical antibiotics were prescribed and cultures obtained. Clinicians using single antibiotics (anti-MRSA [Table 4A] or anti-MSSA [Table 4B]) used monotherapy that accurately targeted the resultant cultured pathogen accurately 39.3% of the time Inhibitors,research,lifescience,medical (ranging from 35-52% depending on age and treatment strategy). Anacetrapib Cultured SSTIs from 100% of pediatric patients and 67.8% of adult patients treated with multi-drug “double coverage” (Table 4C) grew only Staphylococcus. Table 4 Empiric antibiotic treatment and targeted organisms in microbiologic culture Table 5 displays the univariable logistic regression analyses investigating demographic and clinical correlates of coverage of the resultant pathogen with the chosen antibiotic regimen, “double coverage” antibiotic usage, and discordance of empiric MRSA therapy (use of anti-MRSA antibiotics in the absence of MRSA, or vice versa). Table 5 Logistic models to identify factors associated by univariate analysis with coverage of the isolated organism by the antibiotic prescribed (A), treatment with multiple antibiotics (“double coverage”) (B), and discordant anti-mrsa therapy …